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In-vivo real-time monitoring of neurotransmitter in mouse brain for study of neurodevelopmental disorders


Real-time monitoring of brain neurotransmitters, such as dopamine and serotonin is the key in understanding the biological bases of neurodevelopmental disorders and also in the development of novel therapeutic agents for the treatment. Current method for detecting brain neurotransmitters such as HPLC requires large sample volume and takes long time for sample collection. Dr. Wang has been developing a novel label-free biosensor based on ultraviolet plasmonic enhanced native fluorescence. The UV plasmonic sensor is label-free and does not require signal enhancement from enzyme or nanoparticles, thus can significantly improve the detection speed. The sensor requires very small sample volume and can be integrated into the microdialysis apparatus to realize real-time monitoring of brain neurotransmitters.
The project will be a new cross campus collaboration between the College of Engineering (Drs. Yunshan Wang, Steve Blair and Jules Magda), College of Pharmacy (Dr. Marco Bortolato). The proposal addresses the University’s four strategic goals: 1) Generate new knowledge regarding to plasmonic enhancement of native fluorescence of neurochemicals. 2) Provide experience to graduate students and undergraduate students working in an interdisciplinary environment 3) Contribute our understanding in neurodevelopmental disorders and facilitate the development of treatment methods. 4) Cultivate One U partnerships across campus and within our communities.

Collaborators

YUNSHAN WANG
College of Engineering
Chemical Engineering
Project Owner

STEVEN BLAIR
College of Engineering
Elect & Computer Engineering

MARCO BORTOLATO
College of Pharmacy
Pharmacology And Toxicology

JULES MAGDA
College of Engineering
Chemical Engineering

Project Info

Funded Project Amount
$30K

Keywords
neurotransmitter, dopamine, brain, in-vivo, plasmonics, ultraviolet, fluorescence

Project Status
Funded 2020
Last Updated: 1/23/20